Pivot Park Screening Centre
The Pivot Park Screening Centre (PPSC) provides its customers and partners the best confirmed leads for development of new medicines.The open access facilities provide instrumentation for hit-to-lead testing and technology development.
Our open access laboratory is designed to provide you with an easy-to-use automation infrastructure for all in-vitro testing experiments in microtiter plates (assay development, screening, follow-up, hit optimisation, high content analysis and lead optimisation). With a broad selection of instruments, this lab is an ideal environment for technology development. The open access lab saves you time and investment in equipment and specialised staff. This enables you to scale up your experiments quickly and in a flexible manner. You can perform your experiments efficiently using your own biology and our automation and expertise.
At the basis are our state-of-the-art automation – two fully automated robotic systems – and our team which has more than two decades of proven experience in High Throughput Screening (HTS). S
We are based at Pivot Park. Pivot Park offers companies a high-end pharma R&D infrastructure, which provides the opportunity to accelerate, grow and excel in development of new medicines. When working at Pivot Park you’re automatically part of an active, innovative pharma R&D community, which acts as a hub to an even wider international network and contributes to a healthy society.
In our open access lab you have access to the following automation:
Multimode plate reader for measurement of fluorescence, chemoluminesce or absorption – TRF, HTRF, Fluorescence Polarization, AlphaScreen 96, 384 en 1536 wells
Automated fluorescence microscope for High Content Screening in microtiter plates for instance 96 and 384 wells.·
Fluorometric Imaging Plate Reader Measurement of calcium ion fluxes and kinetics in microtiter plates for instance ion channels, GPCRs, membrane potentials. Possibility to measure luminesce. 96, 384 en 1536 format. Simutaneous Pipet and Read function. Phenotypic sceen (cardiomyocytes). BRET measurement
Pipetting robot with needles (cherrypicking) and multichannel heads (96 and 384 and 1536 format). Plate reformatting, cherry picking, serial dilutions, DMPK (ADME) studies.
Echo (acces on demand)
Acoustic dispensing for flexible contact free and low volume dispensing (nano liter range), plate to plate transfer, cherry picking, focused libraries. ·
Centrifugal washing technology for microtiter plates for
instance for ELISA or cellular assays; 96, 384 and 1536 wells.
ORCA robotic platforms
Automated handling of large batches of microtiter plates.
Besides our open access lab we offer tailor-made and efficient assay development followed by (ultra) HTS and profiling services. Screening can be performed on both our own library, consisting of 300.000 high quality drug-like compounds, and client libraries up to 2.5 million compounds. Optionally, libraries can be shared between clients to gain access to a larger chemical space. Read more about this in our brochure.